Mesotrione

1 Trade nameManufacturerForm
CALLISTO HerbicideSYNGENTA AUSTRALIA PTY LTDSUSPENSION CONCENTRATE

2 PRICE:

$85.8/L

3 ACTIVE INGREDIENTS: Mesotrione 480g/L

4 CHEMICAL GROUP: H

5 RELATED HERBICIDES:

BalanceIsoxaflutole 750 g/kg (or480g/L)
Benzofenap 300Benzofenap 300g/L
MesotrioneMesotrione 480g/L
TopramezoneTopramezone60g/L+Cloquintocet-mexyl60g/L

6 GENERAL DESCRIPTION:

A pre emergence, root absorbed, residual herbicide applied as spray in water and incorporated by sowing for the control of broad leaved weeds in wheat and barley.

7 APPLICATION METHODS AND TIPS:

Best results with knife point seeders on clod free soil, with light train a few days later.
Incorporate by sowing (IBS) within 3 days of application.
Do not apply if heavy rains or storms are forecast within 3 days.

Do not irrigate to the point of runoff for at least 3 days after application.
Do not cultivate before application or cultivate after incorporation by sowing.
Harrowing dilutes herbicide and reduces weed control.

8 WEATHER:

Rainfast in 0 hours .
Frost effects: Little effect.
Wind: 3-20 km/hour to reduce the risk of drift.
Inversions: Do not apply during hazardous temperature inversions.
Temperature: Little effect.
Delta T and relative humidity: Little effect.

9 ADJUVANTS:

Wetting agents: Not required.
Spray oils: Not required.

10 WATER QUALITY:

Hard water:
Salty water:
Colloids:
pH:
Tank life: Long unless mixed with metolachlor.

11 COMPATIBILITY:

Trace elements.
See HerbiGuide Compatibilities button.

12 EQUIPMENT:

Boom sprays:

Carrier volume: >50 L/ha.
Nozzles: Flat fan.
Pressure: 150-400 kPa.
Droplet size: Medium or larger advised by APVMA to reduce drift.

Aerial application:

Carrier volume:

13 SPRAYER DECONTAMINATION:

Clean Up:

Clean soon after spraying to reduce the risk of forming dried deposits that may be difficult to remove.
Remove filters and clean separately. Rinse with soapy water (e.g. 500 mL or g of Drive, Dynamo, Omo or Surf per 100 L water) or water plus 0.25% wetting agent and run through boom. Rinse with water.

Decontamination:

Remove filters and clean then soak in 500 mL of 3% household ammonia in 10 L water for 30 minutes.
Rinse sprayer with soapy water (e.g. 500 mL or g of Drive, Dynamo, Omo or Surf per 100 L water) or water plus 0.25% wetting agent and run through boom. Fill with 1 litre of 3% household ammonia per 100 litres of water and circulate for at least 15 minutes (allow to stand for several hours if possible). Triple rinse with water. Or use a commercial spray tank and equipment cleaner.
Rinse nozzles and filters in water and replace then rinse the whole system with water again.
Don't use chlorine based cleaners in combination with ammonia.

14 HERBICIDE RESISTANCE:

Tolerant plants are expected to occur and may dominate the weed population after repeated applications.

15 REPLANTING INTERVALS:

CropTime
Canola, Chickpeas, Faba Beans, Field Peas, Medic, Lentils, Lucerne, Lupins, Sub Clover, Vetch9 months plus 250 mm rain.

16 WITHHOLDING PERIODS:

CropTypeTime
AllGrazing10 weeks
AllHarvestNot required when used as directed
MRL of *0.01 mg/kg for grain and straw.
**0.01 mg/kg for MO 0105 edible offal (mammalian)
**0.01 mg/kg for PE 0112 eggs
**0.01 mg/kg for MM 0095 meat (mammalian)
**0.01 mg/kg for ML 0106 milks
**0.01 mg/kg for PO 0111 poultry, edible offal of
**0.01 mg/kg for PM 0110 for poultry meat.
* = Limit of detection.

17 RE-ENTRY PERIOD:

Wear protective clothing if in contact with the crop before the spray has dried.

18 PROTECTIVE CLOTHING:

Overalls, boots and washable hat. Use gloves and face shield when handling the concentrate.

19 SOIL:

Soil texture: Crop damage is more likely on sandy soils.
Soil pH:
Soil organic matter:
Soil moisture at application:

20 MODE OF ACTION:

It inhibits the HPPD enzyme (4-hydroxyphenylpyruvate dioxygenase), the second enzyme in the catabolic pathway of tyrosine. This prevents carotenoid pigment formation, which in turn leads to chlorophyll degradation and yellowing of leaves.
It is a member of the triketone group of herbicides or Group H.

Uptake and translocation: Absorbed through the roots

Physiological effects: Causes chlorosis (leaf yellowing).

Residual Life and Breakdown: Mesotrione is slightly soluble and may redistribute through the soil profile depending on soil texture, soil organic matter and rainfall patterns.

21 SELECTIVITY:

Crop tolerance:

May cause transient yellowing.

Varietal sensitivities:

Effect on Clover Species: Damages clover.

Effect on Medic Species: Damages medics.

Effect on Lucerne:

Effect on Native Plants: Established native plants are usually tolerant.

22 DISEASE AND INSECT EFFECTS:

23 PLANT SYMPTOMS:

Affected plants turn white or pale yellow before dying.
Transient bleaching of newly emerged crop leaves lasting around 2 weeks may occur, especially where high rates are used on sandy soils where furrow walls collapse.

SECONDARY EFFECTS:

24 TOXICITY:

Summary:

Very toxic to aquatic life with long lasting effects.
May irritate the eyes and skin.

Details:

SUSMP classification (Poison schedule): S6.
Mammalian toxicity: Low.
Acute oral LD50: >5000 mg/kg (rat), [For comparison table salt is 3000 mg/kg]
Acute dermal LD50: >2000 mg/kg (rabbit).
Skin: Not iirritating. It was not a skin sensitiser
Eye: Not irritating in tests.
Vapour inhalation: LC50 >5.19 mg/L air (rat). No acute inhalation toxicity.
Not carcinogenic, mutagenic or teratogenic in animal studies (i.e. does not cause cancer in animal tests).
The NOAEL for reproductive effects appears to be around 70 mg/kg bw/day for mice. There was no evidence of genotoxicity.
There was no evidence of any neurotoxic effects in an acute toxicity study or a three month repeat-dose toxicity study in rats.
Chronic oral toxicity: NOAEL 1212 mg/kg bw/day for 90 days for mice and 100 mg/kg bw/day for dogs. The NOAEL in 12-18 month studies on mice was 50-56 mg/kg bw/day.
The main adverse toxicological finding following steady-state exposure to dietary mesotrione was elevated plasma tyrosine levels resulting in ocular lesions, with rats being especially sensitive.
Acceptable Daily Intake (ADI): 0.5 mg/kg bw/day
Acute Reference Dose (ARfD): Establishing an ARfD for mesotrione was considered unnecessary due to its low acute oral toxicity and the absence of any developmental toxicity after a single oral dose in experimental laboratory animals.
Mesotrione was rapidly absorbed (peak plasma concentrations within two hours of dosing) and rapidly excreted unchanged in the urine within 12 hours of dosing.

Other Species:

Birds: toxicity.
Fish: toxicity LC50 12.5 mg/L (96 hour)
Invertebrates: toxicity. Daphnia magna (Water flea):EC50 >180 mg/L (72 hour)
Lemna gibba (gibbous duckweed): EC50 = 0.012-0.022 mg/L. NOEC = 0.0025-008 mg/L.
Bees: toxicity.
Arthropods: toxicity.
Earthworms:
Algae: ErC50 (Pseudokirchneriella subcapitata (green algae)): 0.87-26 mg/L (72 hour). NOEC: 0.18 mg/L (72 hour).
Microorganisms : EC50 (Pseudomonas putida): > 10,000 mg/l

25 TOXICITY SYMPTOMS:

In mammals, inhibition of HPPD typically leads to increased serum levels of tyrosine.

26 FIRST AID:

If SWALLOWED: Wash out mouth with water. Do NOT induce vomiting Do NOT give anything by mouth to a semiconscious or unconscious patient. Seek medical advice immediately.
If in EYES: Hold eyelids open and wash eyes with plenty of water for 5 minutes, remove contact lenses if present and wash for a further 10 minutes. Immediate medical attention is required.
If on SKIN: Remove contaminated clothing. Wash skin thoroughly with soap and water. If irritation persists, seek medical advice.
If INHALED: Remove patient to fresh air. Call a doctor or Poisons Information Centre immediately.

Advice to doctor: Treat symptomatically. No specific symptoms known or expected. May cause increased serum levels of tyrosine.
Contact the Poisons Information Centre on 131126.

27 ENVIRONMENTAL FATE:

Half life in soil: >30 days. Dissipation time: 6-105 days. Product is not persistent.
Half life in water: Persistent in water. days at pH5 and 35 C.
It has an EPA classification for soil mobility that ranges from medium to high mobility in soil.
It has a leaching index of . (for comparison, trifluralin is 0-1 and chlorsulfuron is 25-30).
Ground water contamination:
Accumulation in milk and tissues:
pH stability:
Photolysis rate:
Hydrolysis half life: Photo-degradation in water
Biodegradation rate:
Bioconcentration factor (BCF):
Residues in produce: The metabolic pathway for mesotrione breakdown in plants is largely based on:
*hydroxylation of the cyclohexanedione ring or by oxidative cleavage to MNBA
*reduction in the nitro group to give AMBA
*de-amination of AMBA to form MBA.
Residues of mesotrione and its metabolites were low in grains, <5 per cent of the TRR, with the exception of soya bean grain where mesotrione represented 10 per cent of the TRR.
In livestock, the metabolic pathway for mesotrione is largely based on:
*oxidative cleavage of the parent compound to MNBA
*reduction in the nitro group to give AMBA.
For all animals the majority of the TRR was excreted (at least 91% in cows, 90% in hens, and 89% in pigs).
Levels in milk were low for mesotrione and it breakdown compounds.
Low bioaccumulation potential.

28 REGISTERED CROPS:

See HerbiGuide Species Solution tab.

29 REGISTERED WEEDS:

See HerbiGuide Species Solution tab.

30 REGULATION AND LEGAL:

APVMA Numbers: 87588.
UN number: 3082
CAS numbers: 104206-82-8
OPP Chemical Code:
Hazchem code: 3Z.
SWA classification:
Land transport: ADG
Dangerous goods class (ADG): Not classified as a dangerous good.
Sea transport: IMDG
International Maritime Dangerous Goods Code (IMDG):
Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (MESOTRIONE)
Technical Name: MESOTRIONE
Hazard Class: 9
ID Number: .
Packaging group: III
EMS Number: F-A, S-F.
EPG:
Marine Pollutant: Yes.
Air transport: IATA/ICAO
Proper Shipping Name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (MESOTRIONE)
Technical Name: MESOTRIONE
ID Number:
Packaging group: III
Cargo Packing Instructions: 964.
Passenger Packing Instructions:
Environmental Hazard: Yes.

Risk phrases:
Safety phrases:
Hazard Statements:
H373 May cause damage to organs (Kidney) through

prolonged or repeated exposure.
GHS Classification:

Specific target organ toxicity - repeated exposure: Category 2 (Kidney)
Hazard Symbols:
Records: Are required within 24 hours and kept for 2 years.
Buffer zones:
Not required for bystander, pollinator or livestock areas.
Mandatory downwind buffer zones
RateBoom height above the canopyNatural aquatic areas Vegetation
areas
Livestock
areas
Label rate0.5 m or lower 70 metres 95 metres Not required
Label rate1.0 m or lower 200 metres 325 metresNot required
<100 mL/ha0.5 m or lower 40 metres50 metresNot required
<100 mL/ha1.0 m or lower 110 metres140 metresNot required

31 PROPERTIES:

Colour: Light brown coloured liquid. Technical is a Pale yellow to amber solid.
Odour: Odourless to slightly sweet
Form: Technical is a solid granular powder. Formulated as a suspension concentrate normally.
Chemical name: mesotrione (ISO).
Empirical formula: C14H13NO7S
IUPAC: 2-(4-mesyl-2-nitrobenzoyl)cyclohexane-1,3-dione
CAS: 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione
Water solubility: Miscible.
Oil solubility: Soluble in most organic solvents. E.g. Methanol 3.7 g/L, Ethyl acetate 17 g/L, Toluene 2.7 g/L, Dichloroethane 89 g/L, Acetonitrile 104 g/L, Xylenes 1.4 g/L, Heptane < 0.3 g/L, Acetone 81 g/L.
Octanol:Water ratio: at 25 C
Log Pow = 1.15 at pH 5
log Pow = -2.4 at pH 6.8
log Pow = -2.6 at pH 9.0.
Soil organic carbon absorption coefficient (Koc):
Vapour Pressure: <5.7 x10-6 Pa at 20 C.
Henry's Law constant: < 5.1 x 10-7 Pa m3/mol
Vapour density:
Dissociation constant: pKa
Melting point: C.
Boiling point: .
Molecular weight: 339.3 g/mol
Bulk density: 1.19 g/cm3 (25 °C).
Specific gravity:
Viscosity: 2,760 mPa.s ( 20 °C), 2,110 mPa.s ( 40 °C).
Surface tension: 44.6 mN/m, 20 °C.
pH: 1-5 at a 1% dilution in water at 20 C. 2.4-2.8 at 100% w/v.
Flammability: Non flammable. Not explosive. Contains combustible organic components.
Flashpoint: Does not flash.
Autoignition: 405 C.
Corrosivity: Non corrosive.
Shelf Life: >2 years when stored under ideal conditions. Stable for over a year at 20 C. 1% decomposition per 2 weeks at 54 C.
UV/VIS absorption spectra: ëmax 256 nm.
Hydrophilic.

32 SPILLS:

Absorb spill with earth, sand, clay or absorbent material such as vermiculite.
Clean with detergents. Avoid solvents.
Ventilate area after cleanup.

33 FIRE:

Extinguish with water spray, foam, carbon dioxide or dry agent.
Toxic fumes may be released in fire. Wear breathing apparatus or avoid smoke.

34 COMMENTS:

35 REFERENCES:

Syngenta (2020) Callisto label MESO480_87588-118718
Syngenta (2020) Callisto SDS MMESO480_87588-0120
APVMA (2019, 2020)

Acknowledgments:

Collated by HerbiGuide. For more information see www.herbiguide.com.au or phone 08 98444064.