Propyzamide 500

Propyzamide 500

1 Trade name	Manufacturer	Form
4FARMERS PROPYZAMIDE 500 WP HERBICIDE	4 FARMERS PTY LTD	WP
BARMAC POA PRO SELECTIVE HERBICIDE	BARMAC INDUSTRIES PTY LTD	SC
BURST 500SC HERBICIDE	SIPCAM PACIFIC AUSTRALIA PTY LTD	SC
BURST HERBICIDE	SIPCAM PACIFIC AUSTRALIA PTY LTD	WP
CHEMAG EDGE 500 WP HERBICIDE	IMTRADE AUSTRALIA PTY LTD	WP
CLEARWAY 500 HERBICIDE	GROW CHOICE PTY LIMITED	SC
DAVID GRAYS WINTER GRASS KILLER	DAVID GRAY & CO. PTY LIMITED	LD
DOW AGROSCIENCES KERB 500 SC SELECTIVE HERBICIDE	DOW AGROSCIENCES AUSTRALIA LIMITED	SC
FARMOZ ROYALE 500 SC SELECTIVE HERBICIDE	FARMOZ PTY LIMITED	SC
KERB SELECTIVE HERBICIDE	DOW AGROSCIENCES AUSTRALIA LIMITED	WP
TRADELANDS PROPYZAMIDE 500 SC SELECTIVE HERBICIDE	TRADELANDS PTY LTD	SC
YATES WINTER GRASS KILLER	ORICA AUSTRALIA PTY LTD	WP

2 PRICE:

$33.5	/kg
$33.5	/L

3 ACTIVE INGREDIENTS: Propyzamide 500g/kg or L

Sometimes referred to as pronamide in older literature.

3,5-dichloro-n-(1,1-dimethyl-2-propynyl)-benzamide

4 CHEMICAL GROUP: D.

Amides.

5 RELATED HERBICIDES:

Chlorthal	Chlorthal 750g/kg
Oryzalin plus trifluralin	Oryzalin 125g/L + Trifluralin 125g/L
Propyzamide 500	Propyzamide 500g/kg or L
Stomp 330	Pendimethalin 330 or 445g/L
Surflan	Oryzalin 500 g/L
Trifluralin 480	Trifluralin 480g/L

6 GENERAL DESCRIPTION:

A foliar and root absorbed, translocated, residual, pre and post emergent agricultural herbicide with action on a broad range of grass and some broad leaved weeds in some broad leaved crops, pastures and turf.

7 APPLICATION METHODS AND TIPS:

Best results when applied to small weeds in cool, moist soils and rain follows a day or two later.

8 WEATHER:

Rainfast in hours.

Frost effects:

Wind:

Inversions:

Temperature:

Delta T and relative humidity: Avoid application when Delta T is greater than

Soil moisture at application:

9 ADJUVANTS:

Wetting agents:

Spray oils:

10 WATER QUALITY:

Hard water:

Salty water:

Colloids:

pH:

Tank life:

11 COMPATIBILITY:

Trace elements.

See HerbiGuide Compatibilities button.

12 EQUIPMENT:

13 SPRAYER DECONTAMINATION:

Clean Up:

Remove filters and clean separately. Rinse with soapy water or water plus wetting agent and run through boom. Rinse with water.

Decontamination:

Remove filters and clean then soak in 500 mL household ammonia in 10 L water for 30 minutes.

Rinse sprayer with soapy water (eg 500 mL or g of Drive, Dynamo, Omo or Surf per 100 L water) or water plus 0.25% wetting agent and run through boom. Fill with 1% solution of ammonia and allow to stand for several hours. Triple rinse with water. Or use a commercial spray tank and equipment cleaner.

Rinse nozzles and filters in water and replace.

Don't use chlorine based cleaners.

14 HERBICIDE RESISTANCE:

15 REPLANTING INTERVALS:

Crop	Time
Buffalo Grass	60 days
Cereals	12 months
Common Couch	60 days
Queensland Blue Couch	60 days

16 WITHHOLDING PERIODS:

Crop	Type	Time
Clover	Grazing	25 days
Clover	Harvest	25 days
Lettuce	Grazing	25 days
Lettuce	Harvest	25 days
Lucerne	Grazing	25 days
Lucerne	Harvest	25 days
Medics	Grazing	25 days
Medics	Harvest	25 days
Turf & lawn	Grazing	25 days
Turf & lawn	Harvest	25 days

17 RE-ENTRY PERIOD:

Wear protective clothing if in contact with the crop before the spray has dried.

18 PROTECTIVE CLOTHING:

Overalls, boots and washable hat. Use gloves and face shield when handling the concentrate.

19 SOIL:

Don't on heavy red soils as it appears to be mobile.

Don't use on peat soils as poor weed control will result from excessive binding of the herbicide to organic matter.

20 MODE OF ACTION:

Diverse sites of action.

Group K, amide herbicide.

Uptake and translocation:

Readily absorbed through roots and transported to other parts of the plant. Absorption through the leaves is minimal.

Physiological effects:

Metabolised by both susceptible and tolerant plants.

Residual Life and Breakdown:

30-60 day half life in most soils.

Broken down mainly by microbial action.

21 SELECTIVITY:

Crop tolerance:

Varietal sensitivities:

Effect on Clover Species:

Little effect.

Effect on Medic Species:

Little effect.

Effect on Lucerne:

Little effect.

Effect on Native Plants:

Little effect on most established broad leaved species.

22 DISEASE AND INSECT EFFECTS:

23 PLANT SYMPTOMS:

SECONDARY EFFECTS:

24 TOXICITY:

Summary:

Irritating to eyes and skin. Possible risk of irreversible effects. Repeated overexposure to the active ingredient in this product may cause liver damage.

Toxic to algae.

Primary routes of exposure are inhalation and skin contact.

Details:

Poison schedule: S6.

Mammalian toxicity:

Acute oral LD50: >5000 mg/kg (rat) to >16000 mg/kg, [For comparison table salt is 3000 mg/kg]

Acute dermal LD50: >2000 mg/kg (rabbit) to >10000 mg/kg.

Skin: Slight irritation (rabbit). Will irritate skin.

Delayed Contact Hypersensitivity in guinea pigs: No allergic response observed.

Irritating to mucous membranes (rabbit).

Eye: Slight irritation (rabbit). Will irritate eyes.

Vapour inhalation: LC50 >5 mg/L air (rat) for 4 hours.

Chronic oral toxicity: NOEL 10 mg/kg for two years.

Propyzamide has caused cancer in laboratory animals. It is toxic to the fetus at doses that are toxic to the mother and has cause had effects on reproduction at doses that produced significant toxicity to the parents.

Propyzamide is mutagenic.

Not teratogenic in animal studies.

Acceptable Daily Intake (ADI):

Chronic Data:

The folowing data pertains to studies conducted with the technical material 85% active ingredient:

Decreased body weight and food consumption; increased liver weight; liver thyroid, adrenal and pituitary hypertrophy were observed at 1000 ppm and above in the rat 13 week dietary study. The overall NOEL was 200 ppm (10 mg/kg day) in rats.

Decreased body weight and food consumption; increased liver and adrenal weights and liver histopathology were observed at 500 ppm and above in the mouse 13 week dietary study. The overall NOEL was 100 ppm (16 mg/kg/day) in mice.

Decreased body weight gain and food consumption and increased liver weight were observed at 1350 ppm and above in the dog 13 week dietary study. The overall NOEL was 450 ppm (15 mg/kg/day) in dogs.

Carcinogenicity Data:

The following data pertains to studies conducted with the technical

material 85% active ingredient:

Thyroid adenomas, testicular adenomas, ovarian hyperplasia and liver hypertrophy were observed at 1000 ppm in the rat two-year oncogenicity study the overall NOEL was 40 ppm (2 mg/kg/day) in rats.

Hepatic tumours were observed at 70 ppm and above in the mouse two-year oncogenicity study; the overall NOEL was 13 ppm (2 mg/kg/day) in mice.

Mutagenicity Data:

The following data pertains to studies conducted with technical material

85% active ingredient:

Ames mutagenicity: Negative.

Bacterial DNA damage (rec-assay): Negative

Mouse Lymphoma Point Mutation: Negative

In vitro cytogenetic assay (Chinese hamster lung fibroblasts): Negative

In vivo cytogenetic assay (rat): Negative

In vivo cytogenetic assay (mouse): Negative

Rat Hepatocyte Unscheduled DNA Synthesis: Negative

Mouse Host Mediated Bacterial Gene Mutation Test: Negative

Reproductive/Teratogenicity Data:

The following data pertains to studies conducted with the technical

material 85% active ingredient:

Decreased parental body weight and feed consumtion; liver, adrenal and thyroid hypertrophy and decreased body weight in offspring at 1500 ppm were observed in the rat reproductive toxicity study. The overall NOEL was 200 ppm (10 mg/kg/day) in rats.

Other Species:

Birds: Not toxic. Bobwhite quail, LC50 >10,000 mg/L. Mallard duck, LC50 >10,000 mg/L.

Fish: Low toxicity LC50 96 hour = 4.7 mg/L for Rainbow trout.

Rainbow trout (Salmo gairdneri), 96 Hour LC50 = 72 mg/l

Goldfish, 96 Hour LC50 = 350 mg/l

Guppy, 96 Hour LC50 = 150 mg/l

Channel catfish (lctaluris punctatus), 96 Hour LC50 >200 mg/l

Harlequin fish, 96 Hour LC50 = 204 mg/L.

Invertebrates: Low toxicity. LC50 48 hour > 5.6 mg/L for Daphnia magna.

Bees: Not toxic.

Arthropods: toxicity.

Earthworms:

Algae: Very toxic.

Green Algae (Scenedesmus guadricuada), 96 Hour EC 50 = 5.8 mg/L

25 TOXICITY SYMPTOMS:

26 FIRST AID:

If SWALLOWED: Do NOT induce vomiting. Do NOT give anything by mouth to a semiconscious or unconscious patient.

If in EYES: Irrigate with plenty of water.

If on SKIN: Rinse with plenty of water, remove contaminated clothing, wash with soap and water.

If INHALED: Remove patient to fresh air. See a doctor.

Advice to doctor: Treat symptomatically.

Contact the Poisons Information Centre on 131126.

27 ENVIRONMENTAL FATE:

Half life in soil: Readily degrades with a half life of about 30-60 days. Soil type doen't have a big influence and degradation rates are fairly high even at low temperatures ⁶⁴⁷.

Half life in water: 30 days. Degrades in water.

It has an EPA classification for soil mobility that ranges from

Ground water contamination: In sandy soils it tends not to leach and in clay soils where it is more mobile it tends to be broken down more quickly.

Accumulation in milk and tissues. Low potential for bioaccumulation. Cows fed 5ppm propyzamide had traces of propyzamide in the milk

pH stability:

Photolysis rate: Photodecomposition at the soil surface can also occur. Slowly degraded by light in water.

Hydrolysis half life: Stable to hydrolysis for pH 4.7-8.8. Less than 10% lost over 4 weeks.

Biodegradation rate: Metabolised in plants and animals.

It is readily bound, or adsorbed, to most soils. Increasing soil temperature, and to a lesser extent, soil moisture and pH increase the rate of Propyzamide degradation in soil. In most soil types, there is very little movement, or leaching, of Propyzamide into groundwater as it is nearly insoluble in water. Leaching of Propyzamide residues in soil is most likely in soils with low organic matter content, such as loamy sands or silt loams. Propyzamide is inactivated by soil organic matter and will not be effective on muck, peat, or other very high-organic content soils. Depending upon soil type and climatic conditions, persistence of Propyzamide may be higher. Accumulation of the herbicide from repeated annual applications to the same soil does not appear problematic. Chemical degradation may be the main route of disappearance from the soil. A moderate amount of Propyzamide breakdown is carried out by soil microorganisms. The herbicide is not active against common soil microorganisms. Volatilization loss may be high under hot, dry conditions.

Slowly degraded by microorganisms in water.

28 REGISTERED CROPS:

See HerbiGuide Species Solution tab.

29 REGISTERED WEEDS:

See HerbiGuide Species Solution tab.

30 REGULATION AND LEGAL:

UN number: 3082.

CAS numbers: Propyzamide 23950-58-5. Ethylene glycol 107-21-1 in some formulations.

Hazchem code: 2X.

NOHSC classification: Hazardous

Land transport:

Dangerous goods class: Not calssified as a dangerous good.

Sea transport:

Classified as a dangerous good for transport by sea.

Proper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (PROPYZAMIDE)

Class: 9

Packaging group: III

EPG:

31 PROPERTIES:

Colour: Tan liquid or off white powder.

Odour: Mild to none.

Form: Liquid or powder.

Empirical formula:

Water solubility: 15 mg/L at 25 C at pH for propyzamide; Product dispersible or miscible in water.

Oil solubility:

Octanol:Water ratio: LogPow = 3.1-3.2 at 25 C at pH 5;

Soil organic carbon absorption coefficient (Koc):

Vapour Pressure: 17 mm Hg at 20 C for propyzamide to <0.01 mm Hg quoted.

2266 Pa at 20 C. 0.058 mPa at 25 C for propyzamide.

Volatilization loss may be high under hot, dry conditions.

Dissociation constant: pKa

Melting point: 154 C.

Boiling point: >100 C.

Molecular weight:

Bulk density: 0.2-0.25 g/mL for powder formulations

Specific gravity: 1.14-1.2 kg/L for liquid formulations.

pH: 7-10.

Flammability: Combustible C1. Not flammable under normal use. LFL = 175 g/m3. UFL:

Flashpoint: >100 C.

Autoignition: 428-525 C for a ust cloud. 150 C for a dust layer.

Corrosivity:

Shelf Life: years.

(When Stored under Ideal Conditions)

Stability: Stable under normal conditions.

32 SPILLS:

Absorb spill with earth, sand, clay or absorbent material for liquid formulations. Avoid creating excess dust when cleaning up powdered formulations.

Residues may be cleaned with water and detergent.

Don't allow product to enter drains or waterways as this may cause long term effects on aquatic environments.

33 FIRE:

Extinguish with water spray, foam, carbon dioxide or dry agent.

Toxic fumes may be released in fire. Wear breathing apparatus or avoid smoke.

34 COMMENTS:

35 REFERENCES:

Ashton, F.M. and Crafts, A.S. (1981) Mode of Action of Herbicides. (Wiley-Interscience publication).

Crop Care (1992). Kerb MSDS.

Dow (2001). Kerb label 48555/0801

Dow (2002). Kerb label 54521/1002

Dow (2006). Kerb MSDS 54521/0906

Kearney, P.C. and Kaufman, D.D. (1976). Herbicides. Chemistry, degradation and mode of action. Vol 1 & 2.

Acknowledgments:

Collated by HerbiGuide. For more information see www.herbiguide.com.au or phone 08 98444064.